Powerful superbugs increasingly resistant to antibiotics will wreak havoc in Canada, killing nearly 400,000 Canadians by 2050, suggests a report made public Tuesday.

The grim 268-page report states that deadly bacteria will also put a CAN$400 billion ($302 billion) dent in the country’s gross domestic product.

The report, “When Antibiotics Fail: The growing cost of antimicrobial resistance in Canada,” produced by an expert panel, said the rise of the superbugs will likely grow by 40% by 2050 and increase hospital expenses by CAN$120 billion ($90 billion).

Read more: Superbugs will kill nearly 400,000 Canadians by 2050